Lcmp-00417-2004.r1 Final Accepted Version 1 Cyclic Stretch Increases Vegf Expression in Pulmonary Arterial Smooth Muscle Cells via Tgf-β 1 and Reactive Oxygen Species: a Requirement for Nad(p)h Oxidase
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چکیده
1 CYCLIC STRETCH INCREASES VEGF EXPRESSION IN PULMONARY ARTERIAL SMOOTH MUSCLE CELLS VIA TGF-β 1 AND REACTIVE OXYGEN SPECIES: A REQUIREMENT FOR NAD(P)H OXIDASE Eugenia Mata-Greenwood Albert Grobe 2,3 Sanjiv Kumar Yelina Noskina Stephen M. Black 2,3 From the Department of Pediatrics, Northwestern University, Chicago, IL, the Department of Biomedical and Pharmaceutical Sciences and the International Heart Institute of Montana, Missoula, MT.
منابع مشابه
Reactive Oxygen Species and p38MAPK Have a Role in the Smad2 Linker Region Phosphorylation Induced by TGF-β
Background: Transforming growth factor-β (TGF-β) in addition to the C-terminal region can phosphorylate receptor-regulated Smads (R-Smads) in their linker region. The aim of the present study was to evaluate the role of signaling mediators such as NAD(P)H oxidases (reactive oxygen species [ROS] generators), ROS, and ROS-sensitive p38 mitogen-activated protein kinase (p38MAPK) in this signaling ...
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